OptiMATE Gradient Maker 自動化密度梯度溶液製備儀

用於密度梯度離心樣品溶液製備

OptiMATE Gradient Maker 自動化密度梯度溶液製備儀可將幾乎所有離心前步驟 (包括梯度製備、精確分液和試管封口) 自動化，從而將費力且容易出錯的 密度梯度超高速離心法 density gradient ultracentrifugation (DGUC) 過程簡化為易於維護的操作，大幅縮短運行時間，且不會犧牲純度或產量。

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OptiMATE gradient maker for density gradient centrifugation
OptiMATE gradient maker for density gradient centrifugation

OptiMATE 自動化密度梯度溶液製備儀的特點

自動化分裝與封管

預製漸層

  • 能夠分配線性和階梯梯度
  • 線性梯度的運行時間大幅縮短 (減少 約75% )

簡單的圖形使用者介面 (GUI)與方法(method)建立

  • 訓練新操作員只需數小時，而非數星期
  • 已發佈的方法可確保運行和操作員之間的一致性
  • 梯度數據的可視化

介紹OptiMATE 自動化密度梯度溶液製備儀

 


自動分裝與試管封口

預製漸層

簡單的圖形使用者介面與方法建立

自動化、一致且有效率的漸層式點膠分液


  • 自動分佈階梯梯度和線性梯度，並自動封管

  • 從預先成型的線性梯度開始，可大幅縮短運行時間

  • 改善一致性 - 透過自動化減少錯誤

  • 可在短短數小時內產生高品質密度梯度溶液

  • 與 氯化銫 cesium chloride (CsCl), 碘克沙醇 iodixanol (IDX), 和蔗糖相容
OptiMATE Gradient Maker performance data

Although gradient profiles indicate sufficient separation even at 4 hours, AAV pre-formed experiments (right) were run for 5 hours to improve band resolution/sharpness."

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資源

使用 OptiMATE 自動化密度梯度溶液製備儀快速自動純化腺相關病毒(Adeno-Associated Virus)

 

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使用 OptiMATE 自動化密度梯度溶液製備儀降低病毒載體(Viral Vector)純化的變異性並縮短上手時間

 

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請參閱密度梯度溶液製備試劑

Explore OptiMATE Gradient Maker Models

常見問題

  • Cesium Chloride
  • Iodixanol (OptiPrep™)
  • Sucrose

Sizes
  • 16 mm (8.9 to 13.5 mL)
  • 25 mm (29.9 to 39 mL)
  • 38 mm (94 mL)
Formats
  • Quick-Seal
  • Opti-Seal
  • Open-Top
Materials
  • Polypropylene
  • Ultra-Clear
Filling and sealing performance are impacted by tube material, tube size, and tube volume. Not all tubes meeting the above criteria may be suitable. For a complete list of compatible rotors and tubes, please see the instrument brochure and instructions for use (IFU).

No, OptiMATE is only compatible with ultracentrifuge tubes provided by Beckman Coulter Life Sciences.
Yes, tubing lines are reusable. They have been tested to three runs.

Yes, tubing sets can be sterilized via autoclave or ethylene oxide (EtO).
Density gradient ultracentrifugation (DGUC) is a centrifuge-based technique for providing superior purification of viral vectors (e.g., isolating full AAV particles from partial and empty capsids), along with other materials (such as plasmid DNA) in gene therapy production workflows. DGUC results in a layered gradient based on the density of materials in the original sample.
  • Viruses / viral vectors (e.g., AAV)
  • Virus-like particles and bacteriophage
  • Extracellular vesicles (EVs)
  • Proteins / protein complexes
  • Lipid nanoparticles
  • Synthetic nanoparticles or other nanomaterials
  • Nucleic acids / plasmids
  • Lipemic separations

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