Biomek 4000 Automated Liquid Handler

A compact liquid handler ideal for smaller laboratories and those new to automation. It helps standardize daily pipetting routines, maintain sample quality and generate repeatable, reliable results. Labs focused on genomics, drug discovery, cell biology, proteomics, forensics, and related research can run methods on the Biomek 4000 automated liquid handler.

Ideal for low-throughput workflows
12 deck positions including 4 off-deck
1 - 1,000 µL pipetting volume range with liquid-level sensing
Multiple interchangeable single- and eight-channel pipetting tools and gripper

Biomek 4000 Features

Versatile Workspace

Compact design fits in laminar flow hood or on your lab bench
Up to 12 deck positions including 4 off-deck position that can be used for the integration of thermal cycling, shaking, and waste disposal
Add labware feeders to increase system capacity
Optional enclosure to protect samples from airborne particles
Configurable for specific applications
Download the Biomek 4000 brochure
Watch the Biomek 4000 overview video

Application-Focused Solutions

Biomek-automated demonstrated methods and capabilities for genomic, drug discovery, basic research workflows, and more:

NGS (B42929)
PCR Set-up (B22637)
PCR Clean-up (B22638)
Cell Staining (B22639)
Genomics (B22640)
Liquid Handling (B22867)
CE SDS Sample Prep (B37830)
AC Prep (B37892)
HLA Prep (C23350)

Flexible Pipetting & Workflow Management

Auto-interchangeable single- and 8-channel pipetting tools and gripper
Dynamic volume pipetting range from 1 to 1000 µL
Liquid-level sensing
Supports labware from tubes to 384-well micro/macro and thermal cycling plates
Directional pipetting to any location within the well with controlled aspiration and dispense rates
Efficient wash and bulk dispense tool allows for dispensing against the wall of a well, tip touches, bulk dispense and per liquid volume calibration

Simple System Operation

Biomek Method Launch provides Icon-based programing for drag and drop method and labware loading
Remote instrument monitoring through Google Chrome
Biomek 3D simulator demonstrates method development in real time as you create it
Data Management captures data needed for validation and integrates with LIMS system to import work orders and export data
Optional Biomek Dart software allows live and historical data browsing and reduces manual data integration
21 CFR Part 11 approved

Product Specifications: Biomek 4000

Platform	Biomek 4000
Power Requirements	100-240 VAC, 50-60Hz, 10 A
Software	Biomek software, Biomek Method Launcher, DART 2.0 software

Weight	40.80\|kg / 89.94860297143\|lb
Width	122.50\|cm / 48.2283464566929\|in
Depth	50.50\|cm / 19.8818897637795\|in
Height	67.50\|cm / 26.5748031496063\|in
Package Quantity	1

Documentation and Related Material

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Title	Description
Beckman Coulter Instrument PC Networking Requirements {749D68FB-4893-4B2D-BD6C-C662F0520F64}	This document describes the minimum technical criteria required to connect a Beckman instrument PC to a customer’s local network and/or the internet.
Biomek 4000 Laboratory Automation Workstation {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}	From its enhanced worksurface with interchangeable tools to its flexible, icon-driven software, the Biomek 4000 system adapts to your ever-changing research needs.
Biomek-Automated NGS Library Construction Methods {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}	Next generation sequencing demonstrated methods
Exosome Subclass Analysis {611E05FD-FC41-4E23-9498-DA5662F8D4F9}	Authors: Dr. Kiyotaka Shiba, Dr. Satoshi Yamamoto and Dr. Kazuya Iwai \| Tokyo Japan
Automation of PCR Reaction Setup and AMPure XP Purification Using the Biomek 4000 Workstation {C00ACFAF-8661-4DF6-8BA5-A7A099A7BA9C}	Both polymerase chain reaction (PCR) reaction setup and AMPure XP PCR reagent-mediated purification were automated on the Biomek 4000 Laboratory Automation Workstation.
A Flexible Solution for Automating Cell Staining Using the Biomek 4000 Workstation {C00ACFAF-8661-4DF6-8BA5-A7A099A7BA9C}	The automated Cell Staining Application on the Biomek 4000 Workstation can improve throughput and reproducibility of conventional staining of live and fixed adherent cells.
g-Max: Added Capabilities to Beckman Coulter’s Versatile Ultracentrifuge Line {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Authors: Chad Schwartz, Ph.D., Application Scientist I \| Randy Lockner, M.S., Centrifugation Marketing \| Randy Pawlovich, Director of Product Management & Strategy \| Beckman Coulter, Inc., Indianapolis, IN USA
Automated Illumina TruSeq DNA PCR-Free Sample Preparation on the Biomek 4000 Laboratory Automated Workstation {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Author: David Horvath, M.S. \| Beckman Coulter, Inc.
Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	In this application note, we describe an LC-MS/MS method for the analysis of EtG and EtS in urine employing a simple, automated sample preparation methodology using a liquid handling-based automation system.
Automated Sample Preparation for Cell-Based Assays {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The automation of sample preparation and analysis workflows for a variety of common cellular assays.
Automation of NGS Sample Size Selection using SPRIselect {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	To streamline the NGS sample preparation process, Beckman Coulter has recently launched the SPRIselect Reagent Kit to allow NGS sample size selection to be automated on Biomek liquid handling platforms for high throughput and high efficiency sample preparations.
Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note describes results obtained using a liquid handling-based automation system for the sample preparation of compounds to be analyzed by LC-MS/ MS and applied to the monitoring of multiple classes of pharmaceutical and illicit drugs.
Lab Automation Training Programs {9E29D7A5-B5EC-470A-A5C1-4EF9BFAE9959}	Real-world training options for maximizing the value of your Biomek liquid handling system.
Protection for your Workflows in Automation {9E29D7A5-B5EC-470A-A5C1-4EF9BFAE9959}	Maintenance service plan for Biomek liquid handlers
BeckmanConnect Installation and Activation Instructions {B14306BD-BB46-4B27-BF3E-B11862085BC7}	A step-by-step guide to help you successfully install BeckmanConnect.
Automated Liquid Handling for Cell Staining and Imaging {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Here we describe a variety of automated solutions to reduce the time, effort, and complexity associated with sample preparation workflows for cell imaging.
Automated Illumina TruSeq Nano DNA Sample Preparation on the Biomek 4000 Laboratory Automated Workstation {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Author: David Horvath, M.S. - Beckman Coulter, Inc. \| Published 2016
Reproducible and Efficient Automation of DTR Purification Using the Biomek 4000 Workstation and CleanSEQ {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The Agencourt CleanSEQ* application for the Biomek 4000 Laboratory Automation Workstation is a rapid, high performance dye-terminator removal method utilizing Solid Phase Reversible Immobilization (SPRI) paramagnetic beadbased technology.
High-Performance Exosome Purification and Characterization via Density Gradient Ultracentrifugation and Dynamic Light Scattering {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Exosomes purification and analyses comprise a fast evolving research area; more than 70% of published research on exosomes has been done within the last six years
Automating a Linear Density Gradient for Purification of a Protein:Ligand Complex {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Author: Chad Schwartz, PhD, Application Scientist \| Beckman Coulter, Inc., Indianapolis, IN USA \| Published 2014
Mo Bio PowerMag Soil DNA Isolation Kit on Biomek 4000 Liquid Handling Automation {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Author: Shilpa Parakh, Beckman Coulter, Inc \| Published 2016
Reproducible and Efficient Automation of PCR Reaction Setup and Purification Using the Biomek 4000 Workstation and AMPure XP {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Authors: Ruth Zhang, Li Liu, Amy Yoder, John Palys, Bryan Daniels, Isabel Gautreau and William Godfrey Beckman Coulter Life Sciences, Indianapolis, IN \| Published 2013
Automation of Cell Staining Using the Biomek 4000 Laboratory Automation Workstation {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Manual cell staining of cardiomyocytes, either to characterize antigen expression or to assess cell health, is labor-intensive and time-consuming.
Enzymatic Determination Of Glycerol Contents In Biological Samples Using The Biomek 4000 Laboratory Automation Workstation {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Authors: Dr. Jörg Mampel, B.R.A.I.N Aktiengesellschaft, Darmstaedter Str. 34-36, D-64673 Zwingenberg \| Published 2014
Complete Solutions for your Specific Exosome Workflow from Preparation to Analysis {749D68FB-4893-4B2D-BD6C-C662F0520F64}	Beckman Coulter provides solutions customized for each step in your specific exosome research workflow – from sample preparation to sample analysis – and can also help improve processes and assist with related challenges.
BeckmanConnect Security Highlights {749D68FB-4893-4B2D-BD6C-C662F0520F64}	This document highlights the privacy and security features in the BeckmanConnect remote management solution.

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