Viral RNA Extraction

Reagent Kits: RNAdvance Viral or RNAdvance Viral XP

Extract high-quality RNA from Saliva or Swab Transport Media samples using SPRI paramagnetic bead-based technology. Our viral RNA extraction kits are available for your unique input sample types and collection devices. RNAdvance Viral XP offers higher throughput capabilities and the RNAdvance Viral kit is optimal for extracting from a variety of challenging sample inputs.

  • Produces high-integrity viral RNA for use with PCR-based applications for infectious disease and pathogen research
  • Performance Limit of Detection (LoD) demonstrated at 1 copy/uL for viral RNA
  • Automation-ready, viral extraction quickly adapted to liquid handling platforms

Technical Documents:

RNAdvance Viral XP is listed as an extraction method for use with the Centers for Disease Control’s EUA-authorized COVID-19 test referenced in FDA’s FAQ on testing for SARS-CoV-2. Other than this designation, RNAdvance Viral XP is for research use, and not intended for diagnostic purposes.

 

RNAdvance Viral reagent kit isolates RNA from Saliva and Swab Transport Media
RNA Isolation from Viral Samples RNAdvance Viral XP Reagent Kit

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RNAdvance Viral Genomic Reagent Kits

RNAdvance Viral Workflow Steps

RNA Isolation from Viral Samples Workflow with RNAdvance Viral XP

RNAdvance Viral Product Features

Overview
RNAdvance Viral XP isolates RNA from Universal Transport Media. RNAdvance Viral isolates RNA from Saliva and Swab Transport Media.

High-Quality RNA
The RNAdvance Viral XP and RNAdvance Viral isolation kits purify intact RNA suitable for downstream PCR-based applications. Limit of Detection (LoD) of 1 copy/µL for viral RNA.

Flexible and Scalable
Combining RNAdvance Viral chemistry with automation offers a high-throughput processing solution requiring minimal hands-on-time.

RNAdvance Viral Product Specifications

Application Uses Research Use, RNA Isolation, RNA Extraction, Nucleic Acid Sample Prep, PCR
Format Liquid
Starting Sample Material Saliva and Swab in Universal Transport Media
Automated Available Yes
Item Specifications Referenced C63510

Product Launch Video: RNAdvance Viral XP Reagent Kit

RNAdvance Viral Documentation

Title Description
High-throughput qPCR and RT-qPCR Workflows Enabled by Beckman Coulter Echo Acoustic Liquid Handling and NEB® Luna® Reagents
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Application Note: We show that NEB Luna qPCR reagents offer strong performance in high-throughput qPCR applications and are readily compatible with automated reaction setup, here using the Beckman Echo 525 acoustic liquid handler.
Product Solutions for Viral Research Workflows
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Brochure: Discover product solutions for sample collection, isolation and preparation, virus identification, antibody analysis, and vaccine and therapy development.
Miami Cancer Institute Conducted Virology Research Using RNAdvance Viral
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In this customer spotlight Beckman Coulter Life Sciences had the honor of interviewing Weiming Shen, MS, ASCPCM, Manager of the Genomics Laboratory Service at Miami Cancer Institute, to discuss her team’s progress with virology research.
The Story Behind Warsaw Genomics’ Automated RNAdvance Viral Extraction Workflow
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In this customer spotlight we interviewed Dr. Monika Kolanowska, Scientist and Laboratory Team Leader at Warsaw Genomics, to discuss the collaboration with Beckman Coulter and how they overcame the challenges associated with the accelerated scale-up.
Inactivation of COVID-19 disease virus SARS-CoV-2 with Beckman Coulter viral RNA extraction lysis buffers
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White Paper: We conducted experiments to assess the virus inactivation status after treatment with lysis buffer (LBF) from RNAdvance Viral or RNAdvance Viral XP extraction kits.
Characterization of the Beckman Coulter's RNAdvance Viral XP RNA Extraction Kit using AccuPlex™ SARS–CoV–2 Reference Material Kit
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White Paper: iRepertoire performed analytical performance assays and specimen assays to demonstrate that the RNAdvance Viral XP extraction kit has a limit of detection of RNA (LoD) of 1 copy of RNA, specifically tested with AccuPlex™ SARS–CoV–2 Reference Material Kit, per microliter of sample.
Viral Inactivation Study of SARS-CoV-2 in Lysis Buffer (LBF)
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Technical Note: Review the details and process we uncovered in this inactivation study.
Viral RNA Extraction Performance using RNAdvance Viral Supplemental Protocol
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In this application note we present a research study at Miami Cancer Institute in collaboration with Beckman Coulter Life Sciences using the RNAdvance Viral research reagents described in the Viral Nucleic Acid extraction from swabs using RNAdvance Viral supplemental protocol.
Viral RNA Extraction from Saliva and Swab Samples
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Data Sheet and Performance: SPRI technology enables purification of high-quality RNA with demonstrated compatibility with up to 200 μL of saliva or swab transport media. The protocol can be performed in a single tube or 96-well format with the flexibility to automate on a variety of liquid handling platforms.
Biomek i5 Nucleic Acid Extraction Solution – Viral Nucleic Acid
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Flyer and Method Overview: This method performs extraction of nucleic acid from nasopharyngeal (NP) or oropharyngeal (OP) swabs in transport media, and saliva in a 96-well plate format.
Optimize Sample Purification with the Biomek i5 Nucleic Acid Solution
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Flyer: The Biomek i5 Nucleic Acid Solution combines industry leading automation technology and proprietary SPRI-based chemistry to deliver optimized purification methods for a variety of sample types.
OEM Reagent Kits
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Flyer: By partnering with us as an OEM supplier to develop your genomic assays, you’re committing to a solution that you and your customers can rely on.
Robust and High-Throughput SARS-CoV-2 Viral RNA Detection, Research, and Sequencing using RNAdvance Viral and the OT-2 Platform
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Application Note: We present analytical data showing the SARS-CoV-2 limit of detection (LoD) quantified by qRT-PCR and sequence alignment data that establishes proof of principle for automated sequencing sample and library preparation for possible genetic identification of mutated strains.



Technical Documents